The AUC* or concordance statistic c is the most commonly used measure for diagnostic accuracy of quantitative tests. It is a discrimination measure which tells us how well we can classify patients in two groups: those with and those without the outcome of interest. Since the measure is based on ranks, it is not sensitive…

In this post, I will illustrate the use of prediction intervals for the comparison of measurement methods. In the example a new spectral methodfor measuring whole blood hemoglobin is compared with a referencemethod.But first, let’s start with discussing the large difference between aconfidence interval and a prediction interval. Prediction interval versus Confidence interval Very often…